Publications

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Gregory J. Golden, V. Wu, J. Hamilton, Kevin R. Amses, Melanie R. Shapiro, A. S. Japp, Chengyang Liu, M. Pampena, L. Kuri-Cervantes, James J. Knox, Jay S. Gardner, M. Atkinson, T. Brusko, Eline T. Luning Prak, Klaus H. Kaestner, Ali Naji, Michael R. Betts

bioRxiv, 2024

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

Matthew E Brown, P. Thirawatananond, Leeana D. Peters, Elizabeth J Kern, Sonali Vijay, Lindsey K. Sachs, A. Posgai, Maigan A. Brusko, Melanie R. Shapiro, Clayton E. Mathews, Rhonda L. Bacher, Todd M. Brusko

Diabetologia, 2024

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes

Melanie R. Shapiro, Erin M. Tallon, Matthew E Brown, A. Posgai, Mark A Clements, Todd M. Brusko

Diabetologia, 2024

A genomic data archive from the Network for Pancreatic Organ donors with Diabetes

Daniel J Perry, Melanie R. Shapiro, Sonya W Chamberlain, I. Kusmartseva, S. Chamala, L. Balzano-Nogueira, Mingder Yang, J. Brant, Maigan A. Brusko, MacKenzie D Williams, Kieran M Mcgrail, James A. McNichols, Leeana D. Peters, A. Posgai, J. Kaddis, C. Mathews, C. Wasserfall, B. Webb-Robertson, M. Campbell-Thompson, D. Schatz, C. Evans-Molina, A. Pugliese, P. Concannon, Mark S. Anderson, M. German, C. Chamberlain, Mark A. Atkinson, T. Brusko

Scientific Data, 2023

Diabetes Study of Children of Diverse Ethnicity and Race: Study design

M. Redondo, Kylie K Harrall, D. Glueck, Mustafa Tosur, S. Uysal, Andrew Muir, Elizabeth G. Atkinson, Melanie R. Shapiro, Liping Yu, William E Winter, M. Weedon, T. Brusko, Richard A Oram, Kendra Vehik, William A Hagopian, Mark A. Atkinson, Dana Dabelea

Diabetes/Metabolism Research Reviews, 2023

Human immune phenotyping reveals accelerated aging in type 1 diabetes

Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, P. Thirawatananond, A. Posgai, Leeana D. Peters, K. Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, C. Wasserfall, Michael J. Haller, D. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda L. Bacher, T. Brusko

JCI Insight, 2023

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability

P. Thirawatananond, Matthew E Brown, Lindsey K. Sachs, Juan M. Arnoletti, Wen-I Yeh, A. Posgai, Melanie R. Shapiro, Yi-Guang Chen, T. Brusko

Diabetes, 2023

Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy

Matthew E Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, C. Fuhrman, A. Posgai, Melanie R. Shapiro, T. Brusko

Frontiers in Immunology, 2022

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

Melanie R. Shapiro, Leeana D. Peters, Matthew E Brown, C. Cabello-Kindelan, A. Posgai, A. Bayer, T. Brusko

bioRxiv, 2022

De‐coding genetic risk variants in type 1 diabetes

Melanie R. Shapiro, P. Thirawatananond, Leeana D. Peters, Robert C. Sharp, S. Ogundare, A. Posgai, Daniel J Perry, T. Brusko

Immunology and Cell Biology, 2021

The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes

Robert C. Sharp, Matthew E Brown, Melanie R. Shapiro, A. Posgai, T. Brusko

Frontiers in Immunology, 2021

A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes

Melanie R. Shapiro, T. Foster, Daniel J Perry, R. Rosenfeld, A. Dauber, James A. McNichols, Andrew B. Muir, V. Hwa, T. Brusko, Laura M. Jacobsen

Hormone Research in Paediatrics, 2020

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

Melanie R. Shapiro, Wen-I Yeh, Joshua R. Longfield, J. Gallagher, Caridad M. Infante, Sarah Wellford, A. Posgai, M. Atkinson, M. Campbell-Thompson, S. Lieberman, D. Serreze, A. Geurts, Yi-Guang Chen, T. Brusko

Frontiers in Immunology, 2020

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes

Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde

Journal of Experimental Medicine, 2019

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

Melanie R. Shapiro, C. Wasserfall, S. Mcgrail, A. Posgai, Rhonda L. Bacher, Andrew B. Muir, M. Haller, D. Schatz, J. Wesley, M. V. von Herrath, W. Hagopian, C. Speake, M. Atkinson, T. Brusko

Diabetes, 2019

Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

Melanie R. Shapiro, M. Atkinson, T. Brusko

Current Opinion in Endocrinology, Diabetes & Obesity, 2019

Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes

Christina L. Graves, Jian Li, Melissa Lapato, Melanie R. Shapiro, S. Glover, Mark A. Wallet, S. Wallet

Frontiers in Immunology, 2017

Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways

M. Seeley-Fallen, Lisa J. Liu, Melanie R. Shapiro, O. Onabajo, S. Palaniyandi, Xiaoping Zhu, T. Tan, A. Upadhyaya, Wenxia Song

Proceedings of the National Academy of Sciences of the United States of America, 2014